According to a study, these amino acids work better together. Find out how l-arginine and l-citrulline together better than taking each on their own.

According to a study by the Japanese pharmaceutical and biotechnology company Kyowa Hakko, a combination of l-arginine and l-citrulline works better for nitric oxide activity than either of these amino acids on their own. Their animal study focuses on their patented l-citrulline/l-arginine ingredient. They found that their combination is effective in boosting plasma l-arginine levels, which enhances nitric oxide (NO) bioavailability after taking the supplements.

Research Findings

how to increase staminaAccording to the authors, this combination has shown anti-atherosclerotic effects in the past and the new study supports the idea that these effects may be due to its ability to enhance NO bioavailability. NO is a powerful signaling molecule and researchers have been working to enhance its presence and activity for years. 

“The objective of the present study was to investigate the acute effects of a combination of oral L-citrulline and L-arginine on plasma L-arginine and NO levels, as well as on blood circulation,” wrote the authors. The authors further explained their findings below:

  • “Growing evidences suggests endothelial dysfunction, which is strongly associated with reduced NO bioavailability, to be an initiating factor in cardiovascular diseases. Our data suggests the clinical benefit on vascular function of L-citrulline plus L-arginine supplementation. However, we believe a further study in humans is needed to be able to present a therapeutic option with clinical utility.”

According to their conclusion, their “data show for the first time that a combination of oral L-citrulline and L-arginine effectively and rapidly augments NO-dependent responses at the acute stage. This approach may have clinical utility for the regulation of cardiovascular function in humans.”

L-arginine and L-citrulline

Both l-arginine and l-citrulline are amino acids that serve as precursors to nitric oxide, a natural vasodilator that relaxes and widens blood vessels. As a result, blood can flow more easily, which improves the body’s circulation and delivery of oxygen and nutrients.

l-arginine plusThere are various nitric oxide supplements on the market and they usually have some form of either l-arginine or l-citrulline in their ingredient list. However, based on this study, it seems the best supplements will have a combination of both – the way L-arginine Plus does.

L-arginine Plus combines l-arginine, l-citrulline, Astragin, and various key vitamins and minerals to provide an effective and safe nitric oxide supplement. By taking it, you can boost your circulation, blood pressure health, cholesterol levels, and overall heart health. If you’re ready to give your health the support it deserves, don’t settle for a supplement that contains only one of these ingredients. Give your body the best by getting both l-arginine and l-citrulline in one effective formula and get L-arginine Plus.